Resource Type

Journal Article 344

Conference Videos 52

Conference Information 41

Conference Topics 2

Year

2023 26

2022 69

2021 35

2020 61

2019 43

2018 26

2017 26

2016 20

2015 8

2014 9

2013 3

2012 7

2011 7

2010 9

2009 8

2008 5

2007 9

2006 8

2005 13

2004 11

open ︾

Keywords

DNA 9

informatization 7

DNA damage 6

DNA methylation 6

information technology 6

Cloud storage 4

Machine learning 4

Attribute-based encryption 3

Cyber-physical system 3

Cyber-physical systems 3

Geographic information system 3

Access control 2

CAPP 2

Cloud computing 2

Cyber–physical system 2

DNA assembly 2

Database schemata 2

Information schema constructs 2

Intelligent manufacturing 2

open ︾

Search scope:

排序： Display mode:

Engineering DNA Materials for Sustainable Data Storage Using a DNA Movable-Type System Article

Zi-Yi Gong, Li-Fu Song, Guang-Sheng Pei, Yu-Fei Dong, Bing-Zhi Li, Ying-Jin Yuan

Engineering 2023, Volume 29, Issue 10,   Pages 130-136 doi: 10.1016/j.eng.2022.05.023

Abstract:

DNA molecules are green materials with great potential for high-density and long-term data storageHowever, the current data-writing process of DNA data storage via DNA synthesis suffers from high costsHere, we developed a DNA movable-type storage system that can utilize DNA fragments pre-produced by cellIn this system, these pre-generated DNA fragments, referred to herein as "DNA movable types,"the costly and environmentally hazardous process of de novo DNA synthesis.

Keywords： 合成生物学     DNA信息存储     DNA活字存储系统     经济性DNA数据存储    

HTML PDF Collect

Storage hierarchy oriented DPM policy based on task information

Huang Shaomin,Qi Longning,Yang Jun,Hu Chen

Strategic Study of CAE 2010, Volume 12, Issue 2,   Pages 83-89

Abstract:

Storage hierarchy oriented DPM, which uses buffer to prolong idle time, can achieve lower power than traditional DPM policies. The paper proposes task information based (TIB) policy for storage hierarchy oriented DPM. TIB subdivides the data access mode of tasks and introduces them into policy by modifying access interface to make prefetching and replacement algorithm more energy aware.

Keywords： data buffer     task information     DPM     prefetching policy    

HTML PDF Collect

Development Trend of Laser Technology Application in the Information Field Toward 2035

Research Group of Strategic Research on China’s Laser Technology and Its Application in Information by 2035

Strategic Study of CAE 2020, Volume 22, Issue 3,   Pages 7-13 doi: 10.15302/J-SSCAE-2020.03.002

Abstract:

Laser technology has been widely used in the field of information since it was invented and has promoted the rapid development of information technology, which has become the main driving force for the development of information technology. “Strategic Research on China’s Laser Technology and Its Application in Information by 2035” is a key sub-project of the major consulting project“Strategic Research on China’s Laser Technology and Its Application by 2035” launched by the Chinese Academy of Engineering. It aims to conduct a comprehensive research on the application of laser technology in the information field and on the development of related industries in China; analyze the development trend of laser technology in the information field; and propose suggestions to promote the development of the field. This paper introduces the major application of several laser technologies—optical communication, laser display, optical storage, and optical sensing—in the information field, and analyzes the research and development status of laser technology, the major key technologies, and the development of related industries in China and abroad. To promote the laser technology application in the information field, we suggest that China should establish key research directions and promote the development of core technologies; build an industrial innovation platform to improve technological innovation; lay emphasis on intellectual property protection and strengthen the training of high-end talents; guide the cooperation of government, industry, education, and research to promote achievement transformation; increase policy support and guide the healthy development of the industry; exploit the advantages of industrial agglomeration to enhance the competitiveness of enterprises.

Keywords： laser technology，optical communication，laser display，optical storage，optical sensing    

HTML PDF Collect

Anovel non-volatile memory storage system for I/O-intensive applications None

Wen-bing HAN, Xiao-gang CHEN, Shun-fen LI, Ge-zi LI, Zhi-tang SONG, Da-gang LI, Shi-yan CHEN

Frontiers of Information Technology & Electronic Engineering 2018, Volume 19, Issue 10,   Pages 1291-1302 doi: 10.1631/FITEE.1700061

Abstract:

The emerging memory technologies, such as phase change memory (PCM), provide chances for highperformance storage of I/O-intensive applications. However, traditional software stack and hardware architecture need to be optimized to enhance I/O efficiency. In addition, narrowing the distance between computation and storage reduces the number of I/O requests and has become a popular research direction. This paper presents a novel PCMbased storage system. It consists of the in-storage processing enabled file system (ISPFS) and the configurable parallel computation fabric in storage, which is called an in-storage processing (ISP) engine. On one hand, ISPFS takes full advantage of non-volatile memory (NVM)’s characteristics, and reduces software overhead and data copies to provide low-latency high-performance random access. On the other hand, ISPFS passes ISP instructions through a command file and invokes the ISP engine to deal with I/O-intensive tasks. Extensive experiments are performed on the prototype system. The results indicate that ISPFS achieves 2 to 10 times throughput compared to EXT4. Our ISP solution also reduces the number of I/O requests by 97% and is 19 times more efficient than software implementation for I/O-intensive applications.

Keywords： In-storage processing     File system     Non-volatile memory (NVM)     Storage system     I/O-intensive applications    

HTML PDF Collect

The role of PARP1 in the DNA damage response and its application in tumor therapy

Zhifeng Wang, Fengli Wang, Tieshan Tang, Caixia Guo

Frontiers of Medicine 2012, Volume 6, Issue 2,   Pages 156-164 doi: 10.1007/s11684-012-0197-3

Abstract: ADP-ribosyl)ation of many key proteins in vivo and thus plays important roles in multiple DNAThe present review will focus on recent progress on the role of PARP1 in the DNA damage response andresistance of BRCA-deficient tumors to PARP inhibitors is also briefly discussed from the perspective of DNA

Keywords： PARP1     synthetic lethality     PARP inhibitor     DNA repair     cancer     NHEJ    

HTML PDF Collect

Functional role of ATM in the cellular response to DNA damage

Ming LIU, Wenxiang HU

Frontiers of Chemical Science and Engineering 2011, Volume 5, Issue 2,   Pages 179-187 doi: 10.1007/s11705-009-0268-4

Abstract: our understanding of the mechanism of activation of ATM and its signaling pathways, explore whether DNA

Keywords： ataxia-telangiectasia mutated (ATM)     cell cycle checkpoint     DNA damage     signalling transduction    

HTML PDF Collect

Generation and repair of AID-initiated DNA lesions in B lymphocytes

Zhangguo Chen,Jing H. Wang

Frontiers of Medicine 2014, Volume 8, Issue 2,   Pages 201-216 doi: 10.1007/s11684-014-0324-4

Abstract: AID induces U:G mismatch lesions in DNA that are subsequently converted into point mutations or DNA doubleThus, AID poses a threat to the genome of B cells if AID-initiated DNA lesions cannot be properly repairedregulate the specificity of AID targeting and the repair pathways responsible for processing AID-initiated DNA

Keywords： class switch recombination     somatic hypermutation     activation-induced deaminase     DNA repair     genomic instability    

HTML PDF Collect

Molecular simulation of the interaction mechanism between CodY protein and DNA in

Linchen Yuan, Hao Wu, Yue Zhao, Xiaoyu Qin, Yanni Li

Frontiers of Chemical Science and Engineering 2019, Volume 13, Issue 1,   Pages 133-139 doi: 10.1007/s11705-018-1737-4

Abstract: In , the global transcriptional regulatory factor CodY can interact with the promoter DNA to regulateIn order to study the mechanism of interaction between CodY and its target DNA, molecular docking andARG218, SER219, ASN223, LYS242 and GLY243, among which SER186, ARG218 and LYS242 play a vital role in DNA

Keywords： CodY     DNA     molecular docking     molecular dynamics    

HTML PDF Collect

Environmental pollution and DNA methylation: carcinogenesis, clinical significance, and practical applications

Yi Cao

Frontiers of Medicine 2015, Volume 9, Issue 3,   Pages 261-274 doi: 10.1007/s11684-015-0406-y

Abstract: Studies on DNA methylation are among the earliest and most conducted epigenetic research linked to cancerIn this review, the roles of DNA methylation in carcinogenesis and their significance in clinical medicinewere summarized, and the effects of environmental pollutants, particularly air pollutants, on DNA methylationFurthermore, prospective applications of DNA methylation to environmental pollution detection and cancer

Keywords： environmental pollution     DNA methylation     cancer     biomarker     diagnosis     therapy     prevention    

HTML PDF Collect

Effects of DNA damage on oocyte meiotic maturation and early embryonic development

Shen YIN,Junyu MA,Wei SHEN

Frontiers of Agricultural Science and Engineering 2014, Volume 1, Issue 3,   Pages 185-190 doi: 10.15302/J-FASE-2014035

Abstract: DNA damage is one of the most common threats to meiotic cells.Here, we reviewed exogenous factors which could induce DNA damage.Specially, we addressed the different effects of DNA damage on mouse oocytes and embryonic developmentComplex DNA damage, double-strand breaks, represents a more difficult repair process and involves variousUnderstanding the mechanisms involved in DNA damage responses may improve therapeutic strategies for

Keywords： DNA damage     double-strand breaks (DSBs)     oocyte     embryo    

HTML PDF Collect

Single-Molecule Methods for Characterizing Different DNA Higher-Order Structures Review

Yonglin Liu, Tianyuan Bian, Yan Liu, Zhimin Li, Yufeng Pei, Jie Song

Engineering 2023, Volume 24, Issue 5,   Pages 277-292 doi: 10.1016/j.eng.2022.10.009

Abstract:

DNA is considered to be not only a carrier of the genetic information of life but also a highly programmableDifferent DNA structures are related to their biological and chemical functions.However, the bulk assay ignores the heterogeneity of DNA structures in solution.(ss/dsDNA), DNA higher-order structures, and DNA nanostructures.methods to understand the biophysical properties of DNA and other bio-matter and soft matter.

Keywords： Single-molecule methods     DNA structure     Mechanical properties     Conformational transitions    

HTML PDF Collect

A DNA Computing Model for the Graph Vertex Coloring Problem Based on a Probe Graph Article

Jin Xu, Xiaoli Qiang, Kai Zhang, Cheng Zhang, Jing Yang

Engineering 2018, Volume 4, Issue 1,   Pages 61-77 doi: 10.1016/j.eng.2018.02.011

Abstract:

The biggest bottleneck in DNA computing is exponential explosion, in which the DNA molecules usedTo overcome this bottleneck and improve the processing speed, we propose a DNA computing model to solveIn this article, a 3-colorable graph with 61 vertices is used to illustrate the capability of the DNAAll these tiny strands are operated by DNA self-assembly and parallel PCR.the largest among both the electronic and non-electronic computers that have been developed since the DNA

Keywords： DNA computing     Graph vertex coloring problem     Polymerase chain reaction    

HTML PDF Collect

hydrophobic environment triggering reactive fluorescence probe to real-time monitor mitochondrial DNA

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 1,   Pages 92-102 doi: 10.1007/s11705-021-2063-9

Abstract: Mitochondrial DNA has a special structure that is prone to damage resulting in many serious diseases,Therefore, the rapid and specific monitoring of mitochondrial DNA damage is urgently needed for biologicalIn this design, MBI-CN conjugates to mitochondrial DNA without causing additional damages.significative fluorescence signal changes at 437 and 553 nm within 25 s for the damaged mitochondria DNA, it is a potentially effective detection tool for the real-time monitoring of mitochondrial DNA damage

Keywords： hydrolysis reaction     mitochondrial DNA damage     in situ hydrophobic environment trigger     fluorescence    

HTML PDF Collect

Bacterial inactivation, DNA damage, and faster ATP degradation induced by ultraviolet disinfection

Chao Yang, Wenjun Sun, Xiuwei Ao

Frontiers of Environmental Science & Engineering 2020, Volume 14, Issue 1, doi: 10.1007/s11783-019-1192-6

Abstract: • Long amplicon is more effective to test DNA damage induced by UV. • ATP in bacteria does not degradeWe used quantitative polymerase chain reaction (qPCR) to investigate DNA damage and evaluated adenosineThe results of qPCR effectively showed the DNA damage induced by UV when using longer gene amplicons,in that sufficiently long amplicons of both 16S and gadA indicated that the UV induced DNA damages.

Keywords： UV disinfection     DNA damage     qPCR     ATP    

HTML PDF Collect

Degradation of extracellular genomic, plasmid DNA and specific antibiotic resistance genes by chlorination

Menglu Zhang, Sheng Chen, Xin Yu, Peter Vikesland, Amy Pruden

Frontiers of Environmental Science & Engineering 2019, Volume 13, Issue 3, doi: 10.1007/s11783-019-1124-5

Abstract:

Extracellular DNA structure damaged by chlorination was characterizedlistitem>

Typical chlorine doses will likely effectively diminish extracellular DNA

Plasmid DNA/ARGs were less readily broken downthan genomic DNA.listitem>

The Bioanalyzer methodology effectively documented damage incurred to DNA

Keywords： Antibiotic resistance     Antibiotic resistance genes (ARGs)     Extracellular DNA/ARGs     Chlorination    

HTML PDF Collect

Title Author Date Type Operation

Engineering DNA Materials for Sustainable Data Storage Using a DNA Movable-Type System

Zi-Yi Gong, Li-Fu Song, Guang-Sheng Pei, Yu-Fei Dong, Bing-Zhi Li, Ying-Jin Yuan

Journal Article

Storage hierarchy oriented DPM policy based on task information

Huang Shaomin,Qi Longning,Yang Jun,Hu Chen

Journal Article

Development Trend of Laser Technology Application in the Information Field Toward 2035

Research Group of Strategic Research on China’s Laser Technology and Its Application in Information by 2035

Journal Article

Anovel non-volatile memory storage system for I/O-intensive applications

Wen-bing HAN, Xiao-gang CHEN, Shun-fen LI, Ge-zi LI, Zhi-tang SONG, Da-gang LI, Shi-yan CHEN

Journal Article

The role of PARP1 in the DNA damage response and its application in tumor therapy

Zhifeng Wang, Fengli Wang, Tieshan Tang, Caixia Guo

Journal Article

Functional role of ATM in the cellular response to DNA damage

Ming LIU, Wenxiang HU

Journal Article

Generation and repair of AID-initiated DNA lesions in B lymphocytes

Zhangguo Chen,Jing H. Wang

Journal Article

Molecular simulation of the interaction mechanism between CodY protein and DNA in

Linchen Yuan, Hao Wu, Yue Zhao, Xiaoyu Qin, Yanni Li

Journal Article

Environmental pollution and DNA methylation: carcinogenesis, clinical significance, and practical applications

Yi Cao

Journal Article

Effects of DNA damage on oocyte meiotic maturation and early embryonic development

Shen YIN,Junyu MA,Wei SHEN

Journal Article

Single-Molecule Methods for Characterizing Different DNA Higher-Order Structures

Yonglin Liu, Tianyuan Bian, Yan Liu, Zhimin Li, Yufeng Pei, Jie Song

Journal Article

A DNA Computing Model for the Graph Vertex Coloring Problem Based on a Probe Graph

Jin Xu, Xiaoli Qiang, Kai Zhang, Cheng Zhang, Jing Yang

Journal Article

hydrophobic environment triggering reactive fluorescence probe to real-time monitor mitochondrial DNA

Journal Article

Bacterial inactivation, DNA damage, and faster ATP degradation induced by ultraviolet disinfection

Chao Yang, Wenjun Sun, Xiuwei Ao

Journal Article

Degradation of extracellular genomic, plasmid DNA and specific antibiotic resistance genes by chlorination

Menglu Zhang, Sheng Chen, Xin Yu, Peter Vikesland, Amy Pruden

Journal Article